Reciprocal Changes

Occasionally, a lead view provides a mirror-like representation for the opposite surface of the heart. For example, ST elevation in anterior leads (V1-V4) may present as reciprocal changes in the posterior leads (opposite surface of the heart) as ST depression and possibly even T wave inversion.

Picture this. A 12 lead ECG is taken on a patient who is admitted with crushing midsternal chest pain. On inspection, the patient is in a sinus tachycardia with a heart rate of 108/minute. Five of the anterolateral leads (V3-V6, aVL) show ST elevation by as much as 4 mm. The inferior leads present with ST depression of as much as 4 mm and inverted T waves. Is this patient experiencing an anterolateral MI and further ischemia to the inferior region of the heart? Is it likely to have multiple ischemic regions at the same instant?

No, it is unlikely that two regions are simultaneously ischemic just as it is unlikely that two vessels are occludin at the same time. Instead, the ST depression on this 12 lead is called a reciprocal change.

Why hunt for ST elevation? First, myocardial infarctions (MI) are associated with 12 lead findings of ST elevation (55% of all MI), ST depression (35%) and even with normal or non-specific findings (10%). In hospitals without the ability to perform angioplasties and/or to insert stents into narrowed coronary arteries (percutaneous coronary interventions – PCI), the use of fibrinolytics is administered ONLY to patients experiencing an ST elevation MI (STEMI). Patients receiving fibrinolytics have a 25% reduction in morbidity and mortality. Unfortunately, only those experiencing a STEMI benefit from fibrinolytics. Fibrinolytics are not administered to those experiencing an MI with normal ECG findings or with ST depression because the risk of stroke associated with the fibrinolytics (about 2%) outweighs the possible advantages. Hunt for ST elevation to identify those who would greatly benefit from fibrinolytics and save lives for your actions.

A more apt way to search for reciprocal changes is to conceptualize opposite regions of the heart i.e. anterior and posterior, lateral and inferior. If ST depression is found in lateral leads, ST elevation might be found in the inferior leads (or in the right ventricular leads – V4R – if a 15 lead ECG is obtained).

This brings up an important consideration. Should a 12 lead ECG that only reveals ST depression in two or more leads be followed by a 15/18 lead ECG to hunt for possible ST elevation in mirror leads? Most often the answer is yes. Equipped with the knowledge that reciprocal changes exist and that findings of ST elevation are required to administer fibrinolytics, it is prudent to obtain a 15/18 lead ECG in an effort to search for ST elevation in these alternate lead views.

Possible reciprocal changes include ST depression and T wave inversion. Tall R waves in the anterior leads V1 and V2 (usually deep S waves dominate) may also be reciprocal changes that mirror deep Q waves in the posterior leads. Note that a right bundle branch block also typically presents with upright R waves in leads V1 and V2.

1. Six Second ECG Guidebook (2012), T Barill, p. 148-149

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Dynamic ECG rhythm interpretation
Static ECG rhythm interpretation
Clinical Impact Mapping
Acute Coronary Syndromes Overview
Acute Coronary Syndromes In-Depth
ST Segment & T Wave Differential
Identify Bundle Branch Blocks
15 | 18 Lead View Mapping
Electrical Axis
R Wave Progression
Left Bundle Branch Blocks with ACS
Atypical Findings
Acute Non-Ischemic Disease Conditions
Special Cases

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