Ventricular Hypertrophy

Ventricular hypertrophy is reflected in QRS axis deviation towards the hypertrophied ventricle, increased amplitude in the QRS complex, altered R wave progression, and possibly signs of ventricular strainST depression and T wave inversion.

Note that ST changes can occur from conditions other than myocardial ischemia. A depressed and upward sloping ST segment can represent ventricular hypertrophy.

A reversed R wave progression (large V1 and V2 with S waves in V4-V6) and right electrical axis deviation are common findings with right ventricular hypertrophy (RVH). Similar to right atrial enlargement, RVH occurs with lung disease and pulmonary valve dysfunction.

Left ventricular hypertrophy is reflected in taller than normal R waves in leads V5 and V6. One method involves adding the amplitude of the S wave in lead V1 or V2 to the amplitude of the R wave in V5 or V6. If the amplitudes add to 35 mm or more, strongly suspect ventricular hypertrophy. Also, left ventricular hypertrophy may produce ST depression and T wave inversion (ventricular strain) in the lateral leads V5 and V6.

Ventricular Strain

With severe ventricular hypertrophy, the myocardium can thicken to such a degree that the blood supply to the subendocardium (inner lining of the heart just inside the endocardium) can diminish. As a result, the endocardium is particularly susceptible to hypoxia.

While uncomplicated ventricular hypertrophy affects ventricular depolarization and the QRS complex (i.e. tall R waves), severe ventricular hypertrophy can also affect ventricular repolarization as seen with ischemic changes to the ST segment and T wave. Called a ventricular strain pattern, severe ventricular hypertrophy can cause ST segment depression and T wave inversion (see Figure 6.19).

Not surprisingly, a right ventricular strain pattern may be seen in leads closest to the right ventricle – leads V1 and V2. Left ventricular strain, if present, is usually evident in the lateral leads (I, aVL, V5 and V6).

As mentioned earlier, an echocardiogram should be ordered to prove or disprove 12 lead ECG findings that only suggest possible hypertrophies. The value to being aware of these criteria includes the ability to recognize that ST depression and T wave inversion are not always signs of cardiac ischemia. After all, a 12 lead ECG is performed much more frequently than an echocardiogram. Evidence that supports chamber enlargement or hypertrophy could offer some insight into a patient’s current clinical status, prompting further investigations.

Figure 6.19 Ventricular Strain

Figure 6.19 depicts the QRST ventricular strain pattern. Note the tall R wave that is typical of ventricular hypertrophy. A ventricular strain pattern includes ST depression and T wave inversion typically in leads with tall R waves.

1. Six Second ECG Guidebook (2012), T Barill, p. 88, 154, 173-174

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Dynamic ECG rhythm interpretation
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